The brown recluse spider has a venomous bite and must be treated with care. The bite is initially painless and many are not aware that they have been bitten until a few hours have passed. The symptoms usually include local inflammation and pain. The condition can worsen to include symptoms such as fever, shivering, nausea and itching. If a bite does occur, clean the area with soap and water, apply ice to lessen the pain and seek medical help as soon as possible.